Abstract
A strain of Klebsiella pneumoniae (NB029) was positive for blaTEM (beta-lactamase gene), aph(3’)Ⅰ(aminoglycoside modifying enzyme gene), gyrA (quinolone resistance gene), trbC (genetic marker of plasmids), tnp513, IS26, IS903 (genetic markers of transposons and insertion sequences), intⅠ1 (genetic marker of integrons), qacE△1 (drug efflux gene) by PCR assays. So these positive genes confer multidrug-resistant phenotype. And the presence of gyrA, confirmed as a novel variant (Genbank accession number: JN232083), was determined by sequencing and Blastsguin algorithm. The double mutations at codon 83 and codon 87 in the quinolone resistance-determining region of the gyrA gene lead to high level quinolone resistance.
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