Abstract
(Abstracted from Fertil Steril 2019;112:670–676) It is unclear whether controlled ovarian hyperstimulation (COH) using exogenous gonadotrophins during the in vitro fertilization (IVF) process elevates risk of meiotic or mitotic error, leading to aneuploidy. Several studies with mouse models have suggested that follicle-stimulating hormone (FSH) administration in vitro results in higher rates of aneuploidy, although studies utilizing mouse models are limited due to significantly different rates of aneuploidy and mechanistic differences between mice and humans.
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