Abstract
Abstract Due to increasing concerns on the use of antibiotics in animal production system, development of alternative strategies for disease control in livestock and poultry is becoming important. Avian coccidiosis is caused by several distinct species of Eimeria which undergo intracellular development in different parts of gut reducing significant nutrient absorption. Our previous studies have shown significant protection against coccidiosis using recombinant Eimeria vaccines in laboratory models. This study was carried out to investigate the effect of immunizing 18-day-old embryos with Eimeria profilin protein in novel adjuvant formulation which is composed of Quil A, cholesterol, DDA, and carbopol (QCDC). Chickens which were immunized in ovo with Eimeria profilin/QCDC vaccine produced significantly higher antibody and cytokine responses, and showed better protection against live challenge infection with E. maxima compared to the control chickens which were immunized with Eimeria profilin protein alone. This study demonstrates the first immunological evidence to show immunoenhancing role of QCDC in poultry.
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