Abstract
The results of a systematic experimental study of the retention mechanism of native cyclodextrins (CD) in reversed phase liquid chromatography are reported. They show that the behavior of [alpha]-CD differs strongly from that of the larger [beta]- and [gamma]-CD oligomers. [gamma]-CD shows an unexpectedly high hydrophobic surface for solvent interaction and a reduced interaction with the surface of C18 bonded silica. A study by molecular modeling supports the differences observed between [alpha]-CD, [beta]-CD, and [gamma]-CD. 37 refs., 9 figs., 1 tab.
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