Abstract
Monooxygenase activity (aldrin epoxidation) was measured in microsomal preparations from 51 samples of the Australian sheep blowfly, Lucilia cuprina (Wiedemann), received by this laboratory over the period of a single blowfly season (August 1992-May 1993). Aldrin epoxidase activity varied over a 74-fold range and was significantly correlated with resistance to diazinon; however, we observed no correlation between enzyme activity and cypermethrin toxicity. Field strains displaying some tolerance of diflubenzuron (currently being developed for blowfly control) showed significantly higher aldrin epoxidase activities. Enzyme activity decreased rapidly in subsequent laboratory-reared generations of 4 strains initially showing enhanced activities. However, high levels of activity were maintained over 11 generations in a strain that initially showed high activity. The correlation between diazinon resistance and aldrin epoxidation suggests that the monooxygenase system may contribute to diazinon resistance in addition to the carboxylesterase-mediated resistance mechanism which is the basis of organophosphorus resistance in this species. The enhanced enzyme system present in some field strains appears to provide larvae with some tolerance of diflubenzuron despite no previous exposure to this insecticide.
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