Abstract
In Reply.— Ali et al and Warkel question whether leakage from myocardium might be the possible source of elevated serum CK-MB in marathon runners. We acknowledge this possibility in our discussion by stating, Leakage from either skeletal muscle or myocardium are the only possible tissue sources for the sharply increased levels of serum CK-MB consistently detected in these marathon runners after competition. Normal myocardial scintigraphy concurrent with marked CK-MB levels strongly argues against the heart as the principal tissue source in our view. Dr Warkel is correct that traces of CK are present in other organ systems, but only muscle tissue contains sufficient levels of this enzyme to account for the serum findings. Analysis of CK-MB concentrations in skeletal muscle of runners will clarify the specific muscular source, and such studies are in progress. The two references cited in our introductory paragraph do refer to total serum CK alone rather
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
