Electrosynthesis for the Development of Selective Organic Reactions

Abstract

The development of efficient and selective reactions play a vital role in chemical synthesis and drug discovery, serving as crucial drivers for advancements in these fields. Electrosynthesis has emerged as a versatile and powerful tool within organic chemistry, enabling the exploration and development of new organic reactions. This state-of-the-art technique harnesses the power of electricity to propel chemical transformations, paving the way for synthetic chemists to create intricate organic molecules. In this presentation, we will showcase notable discoveries from the Malapit Lab, highlighting the innovative application of electrochemistry in the exploration of novel and transformative reactions. Among these groundbreaking findings are a site-selective C–H functionalization reaction and the utilization of organoboron reagents to generate diverse carbon-heteroatom products through radical intermediates. These reactions hold promise for the late-stage functionalization of numerous biologically active compounds, presenting exciting opportunities for drug development and synthesis.