Electrospun zinc-based metal organic framework loaded-PVA/chitosan/hyaluronic acid interfaces in antimicrobial composite nanofibers scaffold for bone regeneration applications

Abstract

Metal−Organic Frameworks (MOFs)-loaded electrospun nanofibers have paid much attention to biomedical applications; particularly zeolitic imidazolate framework-8 (ZIF-8) or (Zn-MOF). Electrospun ZIF-8-loaded polyvinyl alcohol/chitosan/hyaluronic acid (ZIF-8@PVA/CH/HA) nanofibrous are constructed, which integrate synthetic nanomaterials with biocompatible mats for bone regeneration. Multifunctional PVA/CH/HA scaffolds embedded with ZIF-8 were fabricated by electrospinner. SEM confirmed the petal shape with a smooth surface for ZIF-8 nanoparticles and successful synthesis of ZIF-8@PVA/CH/HA NFs endowed with excellent morphological structure. The chemical configuration was obtained for all fabricated scaffolds using FTIR and XRD analyses. NFs mats containing ZIF-8 ratios ranged (0, 0.4 and 0.8%, w/v) offered slow-sustained swelling % in water up to 9 days, and gradual weight loss % in PBS (80% degradation rate after more than a week), compared to unloaded ZIF-8 scaffold. Moreover, the results demonstrated that the scaffolds with 0.8% ZIF-8 (PVA/CH/HA/0.8% ZIF-8) recorded sustainable release for ≥6 days; while other scaffolds with (0, 0.2 and 0.4% w/v) ZIF-8 exhibited releasing of ZIF-8 for only 24 h. The treatment of platform with 0.8% MOF showed proficient antimicrobial activities against + G/–G bacteria, pathogens, and fungal cells. The current results refer to the capability of utilizing PVA/CH/HA/ZIF-8 NFs as biomaterials for bone/tissue regeneration, presently.