Abstract
Nanostructured fibrous materials have been made more readily available in large part owing to recent advances in electrospinning and related technologies. Development of nanofibers by using the technique of electrospinning is having a new momentum. The nonwoven structure has unique features, including interconnected pores and a very large surface-to-volume ratio, which enable such nanofibrous scaffolds to have many biomedical and industrial applications, such as tissue engineering, wound dressing, enzyme immobilization and drug delivery. The chemical composition of electrospun membranes can be adjusted through the use of different polymers, In this paper, nanoscaffolds developed by using electrospinning and its applications in tissue engineering, drug delivery and wound healing are reviewed.
Highlights
During the past two decades significant advances have been made in the development of biodegradable polymeric biomaterials for biomedical applications[13]
The specific advantages of electrospun scaffolds make them superior to scaffolds generated by most other techniques for a wide variety of applications
Electrospun scaffold composition and fabrication can be used to provide www.ijbr.ssjournals.com functionality. These advantages are reflected in the wide diversity of scaffolds generated with the intended purposes from biomedical applications
Summary
During the past two decades significant advances have been made in the development of biodegradable polymeric biomaterials for biomedical applications[13]. The major driving force being the longterm biocompatibility issues with many of the existing permanent implants and many levels of ethical and technical issues associated with revision surgeries Linear aliphatic polyesters such as polyglycolide, polylactide, and their random copolymer poly(glycolide- co-lactide) are often used as the base materials for implant devices, such as suture fibers and scaffolds[27,28]. For electrospun nanofibrous scaffolds in biomedical applications, its physical and biological properties, such as hydrophilicity, mechanical modulus and strength, biodegradability, biocompatibility, and specific cell interactions, are largely determined by the materials' chemical compositions[29]. Most of the literature on electrospinning has explored the types of polymer solvent systems from which fibers can be produced
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