Electrophoretic Pattern of Plasma Proteins in Rats treated with Trypan Blue and Ethionine

Abstract

IT is now well known that the liver plays a prominent part in the biosynthesis of the blood plasma proteins which is notably disturbed by every major hepatic injury. We have examined these phenomena in the Wistar rat treated by trypan blue and by ethionine. These substances are chemically different, but they have properties in common, such as hepatoxicity and carcinogenic power with a hepatic tropism. Trypan blue was given by intraperitoneal injections in a 0.5 per cent solution in sodium chloride 9 per cent, for 8 days; the daily dose was of 4 mgm./100 gm. of body-weight in a series of 7 animals and of 8 mgm./100 gm. of body-weight in a second series of 10 animals. These animals were male and were about 3 months old.