Abstract
By using several electrochemical techniques, the voltammetric behavior of alfuzosin (AFZ) based on the oxidation at the carbon nanocomposite electrode designed by incorporation of multi-walled carbon nanotubes (MWCNT) and the ionic liquid 1-hexylpyridinium hexafluorophosphate (HPFP) has been reported. Various characteristics of the electrode were studied by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Differential pulse voltammetry (DPV) was applied as a sensitive procedure for the quantitative determination of AFZ. Concerning optimized experimental conditions, the proposed electrode exhibited substantial sensitivity toward determination of AFZ. Good linearity in the wide range of 2.0×10−8 to 9.0×10−5M was obtained with the detection limit of 4.1×10−9M. Similarly for the amperometric procedure the liner range of 1.0×10−5 to 1.0×10−4M with detection limit of 2.1×10−6M was achieved. To acquire more information about the reaction mechanism and estimating some kinetic parameters, cyclic voltammetry (CV) studies was also performed. The oxidation was irreversible and showed adsorption controlled behavior. The method was successfully applied for the determination of AFZ content in plasma samples.
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