Abstract

In 1971, US President Nixon announced the “war on cancer”. This declaration not only sparked global interest in this devastating disease but also fuelled large investments. Interdisciplinary and international consortia in academic and commercial cancer research and drug development were fostered around the world. Some 40years later, our understanding of the cellular and molecular pathophysiology of many cancer entities has tremendously increased (Hanahan and Weinberg, 2011). This impressive knowledge has led to the establishment of cancer prevention programs, early diagnostics and more effective treatment strategies.

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