Abstract
Background: Electrochemotherapy (ECT), a new palliative treatment for cutaneous metastases, involves the delivery of electrical pulses to lesions several minutes after intravenous or intratumor injection of a chemotherapeutic agent (bleomycin or cisplatin) to facilitate intracellular drug delivery. The local effect of bleomycin is increased by more than 1000-fold. ECT uses low doses of systemic chemotherapeutic agents: it is very specific for tumor cells and spares the surrounding normal tissue, with an excellent safety profile.
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