Abstract
AbstractIn Tris (0.005 mol/L)‐NaCl (0.05 mol/L) buffer solution (pH = 7.10), keeping temperature at 37°C, a highly sensitive reduction peak of the antitumor agent was obtained by linear sweep voltammetry. The peak potential is‐1.56 V (vs. SCE). The peak current is proportional to the concentration of vincristine over the range of 2.1 ± 10−7‐4.2 ± 10−6 mol/L with the detection limit of 1.0 ± 10−7 mol/L. The behavior of the binding of vincristine to tubulin was studied. The results showed that the reaction of tubulin dimer with vincristine formed an electrochemically active complex to be 1:2. Its stability constant is 2.5 ± 1014. The reduction process of the complex is irreversible with adsorptive characteristics.
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