Abstract

Cyclic voltammetry, differential pulse voltammetry (DPV), and chronoamperometry were employed in this study to examine the ganciclovir’s electrochemical behavior on the surface of the modified electrode Fe-Cu/TiO2/multi-walled carbon nanotubes/carbon paste (Fe-Cu/TiO2/MWCNTs/CPE). As such, our proposed sensor proved to be stable while presenting a high sensitivity for the analysis of GCV under the physiological pH value (pH 7.4). Meanwhile, the calibration plots remained linear in the concentration, whose ranges were 25 nM to 40 µM (R2 = 0.996, n = 21) by DPV technique and 0.1 nM to 40 nM (R2 = 0.991, n = 9) through the hydrodynamic amperometry in stirred solutions under optimized conditions. A detection limit of 0.02 nM was obtained while the RSD prove to be 2.3% for six replicate detections of 10 μM GCV. To conclude, the recommended sensor ended up with great sensitivity and selectivity to determine GCV in real samples.

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