Abstract
Studies on acute cats were made to determine the electrical correlates of convulsions produced by chlorinated hydrocarbon insecticides. The most striking polygraphic correlates include: (1) preseizure episodes of hypersynchrony, sporadic rhythmic discharges or spike discharges synchronous in cortex and deep structures, (2) bilaterally symmetrical seizure development, (3) cortical predominance, (4) independent seizure genesis in hippocampus and superior colliculus and (5) induction of seizures by sensory stimulation. Additional studies in mice demonstrate that protection against the effects of chlorinated hydrocarbons afforded by various anticonvulsant drugs parallels the protection these same drugs have against pentylenetetrazol. These findings demonstrate that the striking similarities reported for chlorinated hydrocarbons and pentylenetetrazol in a number of peripheral systems also hold true for the convulsive properties within the central nervous system. They provide a clarification of chlorinated hydrocarbon effects in the central nervous system and provide a rationale for the treatment of chlorinated hydrocarbon poisoning by anticonvulsants effective against pentylenetetrazol seizures
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