Abstract
Methods Twelve healthy women received injection of 1 g acetazolamide or placebo on two separate days in a randomized double-blind crossover study design. We recorded headache on a verbal rating scale from 0-10 during an immediate phase (0-90 min) and a delayed phase (2-12 h). The circumferences of cranial arteries were measured in a blinded fashion using 3T high-resolution magnetic resonance angiography 30 and 60 min after acetazolamide injection.
Highlights
All headache provoking substances are vasoactive and induce an immediate headache in healthy volunteers
Aim To test whether acetazolamide induces headache and dilatation of cranial arteries in healthy volunteers
It is possible that extracellular acidosis induced by acetazolamide causes sensitization of intracranial perivascular nociceptors, which, in combination with vasodilatation, leads to delayed headache in healthy volunteers
Summary
From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014
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