Abstract
Ehlers Danlos syndrome (EDS) is a collagenic disease that has often been associated with different types of sleep disorders ranging from insomnia to obstructive sleep apnea (OSA). EDS usually has associated fatigue and excessive daytime sleepiness (ES), thus narcolepsy should be excluded as a cause. Literature review suggests a high prevalence of hypersomnia disorders in this population. We present two sporadic cases presenting with typical symptoms of narcolepsy.
Highlights
Ehlers Danlos Syndrome (EDS) is a genetic disorder occurring in 1 in 5000 births, with predominance in females
In a recently published retrospective review of 61 predominantly female children with EDS presenting to a tertiary care sleep clinic daytime fatigue occurred in 73.8%, excessive daytime sleepiness (ES) was in 67.2%
Similar to our second case, restless leg syndrome (RLS)/periodic limb movements (PLMS) occurred in 18.0% of individuals, concurring with other conducted studies on narcoleptic individuals showing a higher prevalence of RLS/PLMS compared to non-narcoleptics
Summary
Ehlers Danlos Syndrome (EDS) is a genetic disorder occurring in 1 in 5000 births, with predominance in females. Excessive daytime sleepiness (ES), fatigue, and other sleep disturbances are frequently reported by patients with Ehlers Danlos Syndrome[2,3,4]. MSLT showed an average sleep latency of 2:08 minutes, with three SOREMs confirming the presence of narcolepsy.
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