Eficacia de la crioablación guiada con ecografía en el tratamiento del cáncer de mama de bajo riesgo

Abstract

ObjectivesThe primary objective of this study to determine whether infiltrating carcinoma is present in surgical specimens obtained after ultrasound-guided cryoablation from patients with HER2-negative luminal breast cancer without positive axillary lymph nodes at ultrasound.The secondary objective is to demonstrate that placing the presurgical seed-marker immediately before cryoablation does not interfere with the disappearance of tumor cells from freezing or in the surgeon's ability to locate the tumor. MethodsWe treated 20 patients diagnosed with unifocal HR-positive HER2-negative infiltrating ductal carcinoma measuring < 2cm by means of ultrasound-guided cryoablation (ICEfx Galil, Boston Scientific) using a triple-phase (freezing?passive thawing?freezing; 10min each phase) protocol.All patients later underwent tumorectomy according to the routine operating-room agenda. ResultsNo infiltrating carcinoma cells were detected in the post-cryoablation surgical specimen in 19 patients; a focus of infiltrating carcinoma cells measuring < 1mm was detected in the remaining patient. ConclusionIn the near future, if confirmed in larger studies with longer follow-up, cryoablation might constitute a safe and efficacious technique for the treatment of early, low-risk infiltrating ductal carcinoma. In our series, marking with ferromagnetic seeds did not interfere with the efficacy of the procedure or of the subsequent surgical intervention.