Abstract
A mild, efficient, and C2-selective palladium-catalyzed arylation reaction of indoles, benzofurans, and benzothiophenes with iodobenzenes at room temperature has been developed. The methodology allows the use of water, the most environmentally friendly solvent, as the reaction solvent with the addition of Tween 80 (2% w/w) to increase the solubility of starting materials. The protocol demonstrated wide substrate scope and good yields were obtained for all the 32 examples evaluated (52–93%).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
