Abstract
This paper presents the results of metformin treat- ment in type 2 diabetes patients with initial stages of diabetic neph- ropathy. 25 patients with type 2 diabetes mellitus (DM) with microalbuminuria were under observation. Patients treated with 500 mg metformin two times a day for 12 weeks. It has been shown that using metformin treatment improves the indexes of carbohy- drate and lipid exchange, reduces hyperinsulinemia and concomitant insulin resistance. Using metformin prevents a progress of nephrocardial syndrome in patients with type 2 DM by means of the decline of blood pressure level in daily time, improvements of myocardial diastolic function, reduction of microalbuminuria. Among patients having diastolic dysfunction, the improvement of diastolic function was marked in 56.3%, its normalization happened in 18.8%. In the process of metformin treatment the decline of the body weight is marked with the redistribution of sedimentations of fat toward reduction of visceral obesity.
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