Abstract
AIMS:This study investigates the efficacy of ethanolic extract of Sesamum indicum (EES), vitamin C (VC), and EES + VC in promoting fertility and finding a possible link between their profertility effects and their antioxidant activities.MATERIALS AND METHODS:Forty adult male Wistar rats [Body weight (BW) 186.56 ± 0.465 g] were randomly analyzed into four groups of ten rats each: Control, EESG (EES only), VCG (vitamin C only), and EES + VCG (EES in conjunction with vitamin C). Control was given 5 ml/kg BW/day of normal saline orally; EESG was administered 0.3 g/kg BW/day of EES; VCG was administered 15 mg/kg BW/ day of VC; while EES + VCG was administered both 0.3 g/kg BW/day of EES and 15 mg/kg BW/day of VC. All treatments were for 10 weeks.STATISTICAL ANALYSIS USED:Independent-sample T test was used to analyze the obtained results.RESULTS:The results obtained showed that EES, VC, and more importantly EES + VC are capable of significantly increasing BW gain, seminal parameters, testosterone level, and body antioxidant activities.CONCLUSIONS:These findings lead to the conclusion that EES + VC as well as ESS and VC promote fertility due to both their testosterone-increasing effects and their antioxidant effects.
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