Efficacy of treatment with gonadotropin-releasing hormone analogue alone or combined with recombinant human growth hormone in pubertal short children

Abstract

：Objective To assess theefficacy of gonadotropin-releasing hormone analogue(GnRHa)with or without recombinanthuman growth hormone(rhGH)treatment in Chinese short pubertal children with non-growthhormone deficiency.Methods Of 42 short pubertal children(14 males,28 females)withoutgrowth hormone deftcieney,the average age was(11.6±0.8)year.30 children were treated withslow release GnRHa with initial dose (100μg·kg-1·d-1,28d)and maintenancedose(60-80μg·kg-1·d-1,28d)labdrgGH with initial dose(0.15IU·kg-1·d-1)and maintenancedose(0.10-0.15IU·kg-1·d-1)for at least 1year.16 ofthem were still ongoing till the end of the second year.12 children were treated withGnRHa alone by initial dose(100μg·kg-1·d-1,28d)and maintenance dose(60-80μg·kg-1·d-1,28d),and 7 of themremained on it for 2 years.Dynamic changes including annual growth velocity(GV),boneage(BA)/chronologic age(CA)ratio,Tanner stage,height SDS for CA (HtSDSCA),height SDS forBA(HtSDSBA),and predicted adult height (PAHSDS)were observed.Results By the end of thefirst year tretment with combination therapy,the followingparameters:GV,HtSDSCA,HtSDSBA,and PAHSDS all increased significantly(allP 0.05).Changes in GV,HtSDSBA,and PAHSDS betweenthese two groups were statistically significant(all P 0.05).HtSDSCA,HtSDSBA,PAHSDSincreased(all P>0.05).Changes in GV,HtSDSCA,HtSDSBA,and PAHSDS between these 2 groupswere statistically significant respectively(all P<0.05).Conclusion This combinedtreatment regimen significantly impreved the growth by increasing growth rate and delayingbone matumtion in pubertal chidren without growth hormone deficiency.Further study isneeded to verify beneficial effects on the final height gain. Key words: Idiopathicshort stature; Gonadotropin-releasing hormone analogue; Recombinant human growth hormone