Efficacy of solifenacin with desmopressin acetate monotherapy on children with monosymptomatic nocturnal enuresis

Abstract

Objectives To observe the therapeutic effect of solifenacin on children with monosymptomatic nocturnal enuresis who have poorefficacy after treatment with desmopressin acetate monotherapy. Methods Two hundreds children with monosymptomatic nocturnal enuresis who admitted into our hospital from June 2013 to March 2016 were randomly divided into two groups: 0.1 mg group with 104 caseswere given 0.1 mg desmopressin, 0.2 mg group with 107 cases were treated with 0.2 mg desmopressin, the treatment course was 2 weeks.The children received desmopressin monotherapy with a failure were randomly divided into observation group and control group, 60cases in observation group were given desmopressin combined with 1/3 pill solifenacin, while 62 cases in control group received desmopressin combined with placebo, the treatment course last for 4 weeks and follow up for 4 months, the curative effect and recurrence rate of 2 groups were recorded. Results The effective rate in 0.1 mg group and 0.2 mg group was 40.3%(42/104) and 38.3%(41/107) respectively, with statistically significant difference(P>0.05), the recurrence rate in 0.1 mg group was significantly higher than that in 0.2 mg group four months later[65.7%(23/35) vs. 40.5%(15/37), P<0.05)]. The effective rate in observation group was significantly higher than in control group [28.3%(17/60) vs.4.8%(3/62)], no efficiency and recurrence rate in observation group were significantly lower than incontrol group [46.7%(28/60)vs.79.0%(49/62), 30.8%(8/26)vs.70.0%(7/10)], the differences were statistically significant (P<0.05). Conclusions The high dose of desmopressin in treatment of children with monosymptomatic nocturnal enuresis can reduce the recurrence rate, it combined with the solifenacin can improve the curative effect and get the further reduction in recurrence. Key words: Nocturnal Enuresis; Deamino Arginine Vasopressin; Acetic Acid