Abstract
Two treatments with praziquantel (PZQ) 40 mg/kg, 40 d apart, were given to individuals in a recently established ( 1000 eggs/g). There was no apparent difference in cure rate between younger ( 20 years). No evidence for the existence of a PZQ tolerant strain of S. mansoni was found. Two treatments of PZQ 40 mg/kg, 40 d apart, were sufficient to give an adequate cure rate and high reductions in the intensity of infection. As there was insufficient time for reinfection between treatment and follow-up to result in egg production, the low cure rate observed after one treatment was probably the result of a combination of high infection intensity and the maturation of pre-existing prepatent S. mansoni infections.
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