Abstract
PurposeTo address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?MethodsAfter an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included.Results66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing.ConclusionsBased on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
Highlights
Dental implants have become an integral part of the oral and maxillofacial surgery
The present systematic review aimed to focus on the role of platelet-rich fibrin (PRF) in ridge preservation to addressed the following focused questions: in patients with freshly extracted teeth, what is the efficacy of PRF in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?
The results showed that the A-PRF group underwent significantly lower ridge height reduction compared to the control group
Summary
Dental implants have become an integral part of the oral and maxillofacial surgery. They provide the most comfortable and favorable method to replace lost teeth and reconstruct the esthetic and function for the patients [1, 2]. During the healing period of 3–6 months, the processes of natural alveolar healing interferes with the BSM-based new bone formation and leads to the regeneration of a sufficient implant bed, that allows the delayed insertion of dental implant [16]. There is still no clear evidence about the most suitable time of implant placement [18] Immediate implant placement after tooth extraction has been considered an alternative option to limit alveolar bone resorption [18, 19]. This approach is limited to specific socket morphologies and indications, when a sufficient bone volume is available and the buccal bone is preserved. This method can be applied in combination with BSMs to fill the socket when needed [20]
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