Abstract
BackgroundSuccessful canine sarcoptic mange treatment requires immediate efficacy to eliminate active mites, and sustained activity to prevent re-infestation from in-contact animals and fomites. With extended acaricidal activity, fluralaner has been shown to be effective for treating this disease. To confirm this potential under field conditions, two fluralaner formulations were administered to mite-infested, client-owned dogs.MethodsHouseholds qualified for inclusion if they had at least one dog positive for Sarcoptes scabiei mites, confirmed by skin scraping, and at least one dog with clinical signs evocative of sarcoptic mange. Households were allocated to groups of dogs to receive a single treatment with either oral (Bravecto® chewable tablets, MSD Animal Health) or topical (Bravecto® Spot-on, MSD Animal Health), fluralaner at a dose of ≥ 25 mg/kg (range 25–56 mg/kg) on Day 0, or two treatments with oral sarolaner (Simparica® tablets, Zoetis) (Days 0 and 28) at ≥ 2 mg/kg (2–4 mg/kg). All dogs in each household were treated with the same product. On the enrolment day and subsequently on Days 28, 56 and 84, deep skin scrapings were taken from at least five different body areas judged to be most likely to have active mite infestation. At each visit, the dog’s mange-associated skin lesions were recorded, and pruritus level was assessed.ResultsThere were 98 participating households and 135 dogs enrolled across Albania, France, Italy and Portugal. On Day 28, more than 90% of dogs in each group were negative for mites. On Days 56 and 84, all study dogs were free of mites and most dermatological signs of sarcoptic mange had resolved. There were no treatment-related adverse events in any group.ConclusionsA single treatment of client-owned, sarcoptic mange-affected dogs with either fluralaner chewable tablets or fluralaner spot-on formulation proved a safe and effective treatment of infestations with S. scabiei var. canis, maintained through 84 days (12 weeks) after treatment.
Highlights
Successful canine sarcoptic mange treatment requires immediate efficacy to eliminate active mites, and sustained activity to prevent re-infestation from in-contact animals and fomites
Canine scabies is a non-seasonal, intensely pruritic, transmissible infestation of the skin of dogs caused by the mite Sarcoptes scabiei var. canis [1]
Observations in this study extended to 84 days (12 weeks) following fluralaner administration, which is the expected duration of acaricidal effect after a single administration, based on previous studies [10–12]
Summary
Successful canine sarcoptic mange treatment requires immediate efficacy to eliminate active mites, and sustained activity to prevent re-infestation from in-contact animals and fomites. Fluralaner has been shown to be effective for treating this disease. To confirm this potential under field conditions, two fluralaner formulations were administered to mite-infested, client-owned dogs. Canine scabies (sarcoptic mange) is a non-seasonal, intensely pruritic, transmissible infestation of the skin of dogs caused by the mite Sarcoptes scabiei var. The infestation is highly contagious; and both dogs and their human companions can develop skin lesions after contacting an infested host [1,2,3]. Infestation can occur from contact with a fomite as mites can survive off a canine host for up to 21 days, depending on ambient temperature and relative humidity, with cooler temperatures and lower humidity prolonging survival [1, 4]. Completion of the mite life-cycle, egg to adult, has been estimated at 15 to 21 days [1, 4]
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