Efficacy of individualized homeopathic medicines in irritable bowel syndrome: A double-blind randomized, placebo-controlled trial

Abstract

ContextGastrointestinal ailments are some of the common conditions treated in homeopathy; yet only a few trials have explored the effects of individualized homeopathic medicines (IHMs) for irritable bowel syndrome (IBS). ObjectiveTo explore the efficacy of IHMs in treatment of IBS. DesignDouble-blind, randomized, placebo-controlled trial. SettingOutpatient departments of Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, India. PatientsSixty patients suffering from IBS; randomized to receive either IHMs (n = 30) or identical-looking placebo (n = 30). InterventionsIHMs or placebo in the mutual context of concomitant care in terms of dietary advice, yoga, meditation and exercises. Main outcome measuresPrimary – IBS quality of life (IBS-QOL) questionnaire; secondary –IBS severity scoring system (IBS-SSS) and EQ-5D-5L scores; all measured at baseline and every month, up to 3 months. ResultsGroup differences and effect sizes (Cohen's d) were calculated on intention-to-treat (ITT) sample. Groups were comparable at baseline. Recruitment, retention and attrition rates were 64.5%, 91.7% and 8.3% respectively. Group differences in IBS-QOL total scores, IBS-SSS, EQ-5D-5L scores favored IHMs against placebo overall and at all the time points (all P < 0.001). Pulsatilla nigricans (n = 4, 6.7%) and Thuja occidentalis (n = 4, 6.7%) were the most frequently prescribed medicines. Barring some minor events unrelated to interventions, no harms or serious adverse events were recorded in either of the groups. Thus, IHMs acted significantly better than placebos in the treatment of IBS. Independent replications are warranted. [Trial registration: CTRI/2019/10/021632]