Efficacy of cytoflavin in optimizing the pharmacotherapy of traumatic brain injury

Abstract

Objective. To study the efficacy of Cytoflavinum optimizing the pharmacotherapy of traumatic brain injury.Material and methods. We examined 45 patients with mild to moderate traumatic brain injury aged 25 to 54 years. The patients were divided into two groups depending on the prescribed treatment. The first index group included 25 patients with traumatic brain injury who received complex therapy: Cytoflavinum against the background of standard therapy in accordance with clinical guidelines for the treatment of traumatic brain injury. Cytoflavinum was injected intravenously, once a day, 10 ml in 200 ml of 0.9% sodium chloride solution at a rate of 60–80 drops/min (3–4 ml/min) daily for 7 days. The second control group included 20 patients with traumatic brain injury who received only standard therapy. In accordance with the purpose of the study, laboratory blood parameters and their correlation with the parameters of the antioxidant status were determined, and the dynamics of the clinical condition of patients was assessed.Results and conclusion. The administration of Cytoflavinum to patients contributed to a more pronounced positive dynamics of laboratory blood parameters in comparison with the control. Optimization of the pharmacotherapy of traumatic brain injury by the administration of Cytoflavinum made it possible to achieve a more pronounced regression of clinical symptoms and reduce the duration of hospitalization in comparison with the control group of patients.