Efficacy of BioXtra Spray and Mouthwash in Patients with Radiation-induced Xerostomia: A Randomized Clinical Trial

Abstract

ABSTRACT Aim Xerostomia is an important complication following radiotherapy for head and neck regions producing serious discomfort for patients. Symptomatic treatments for the disease include strict oral hygiene and use of artificial saliva substitutes. The present study compared the efficacy of BioXtra spray and mouthwash in the relief of radiotherapy-induced xerostomia in patients referred to Imam Khomeini Hospital, Tehran University of Medical Sciences. Materials and methods In a cross-over randomized clinical trial, BioXtra spray and mouth wash were used by 20 patients for 2 weeks with a 1 week wash-out period. The ease of application and the patients’ acceptance of the products were obtained using 100 mm visual analog scale (VAS) and dichotomous scales. We used SPSS version. 18.0 to analyze our data considering level of significance less than 0.05. Results Both forms of BioXtra showed similar effect in reducing oral dryness and its complications. The mean VAS was 33.2 for spray and 34.5 for mouthwash. Majority of our patients reported improvements in xerostomia after using spray (85%) and mouthwash (70%), respectively. The patients’ acceptance of both modalities was similar and they showed equal tendency to continue the treatments. No significant differences in symptoms relief as well as judgment of the regimens were found between groups. Conclusion BioXtra spray and mouthwash are similarly effective in reducing the symptoms of postradiotherapy xerostomia. How to cite this article Bakhshi M, Manifar S, Azizi N, Shabestari SB, Mardi AH, Shirinbak I, Mehdipour A. Efficacy of BioXtra Spray and Mouthwash in Patients with Radiationinduced Xerostomia: A Randomized Clinical Trial. Int J Experiment Dent Sci 2014;3(1):19-23.