Efficacy of atorvastatin on diabetic nephropathy and its effect on blood lipid metabolism and renal function

Abstract

Objective To investigate the efficacy of atorvastatin on diabetic nephropathy and its effect on blood lipid metabolism and renal function, so as to provide reference for clinical treatment. Methods A total of 120 patients with diabetic nephropathy were collected and divided into three groups according to the random number table method; the control group (n=40) was treated with valsartan; in addition to valsartan, the observation 1 group (n=40) and observation 2 group (n=40) was treated with 20 mg/d, 40 mg/d atorvastatin, respectively. Clinical efficacy, blood lipid, renal function and inflammatory factor levels were compared among the three groups 3 months after treatment. Results The total effective rate in observation 1 group and observation 2 group were significantly higher than that in control group 3 months after treatment (P<0.05); the urinary albumin excretion rate (UAER), 24 h urinary protein (24 h Pro), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in observation 1 group and observation 2 group were significantly lower than those in control group (all P<0.05); the UAER, 24 h Pro, TC, TG, LDL-C, TNF-α, IL-6 and IL-8 in observation 2 group were significantly higher than those in observation 1 group (all P<0.05). Conclusions Atorvastatin can significantly improve the curative effect on diabetic nephropathy, and improve blood lipid metabolism, renal function and microinflammatory state in a dose-dependent manner. Key words: Diabetic nephropathy; Atorvastatin; Blood lipid metabolism; Renal function; Curative effect