Abstract
Objective The purpose of this study was to assess the efficacy and safety of intravenous 3% hypertonic saline (HTS) compared with mannitol 20% for lowering intraocular pressure (IOP) in patients with glaucoma. Patients and methods A total of 30 patients between age 35 and 60 years with American Society of Anesthesiologist status I–III with glaucoma (IOP=30 mmHg) were enrolled in a double-blind comparative study. Patients were randomized to one of two groups: group GH (n=15), where patients received HTS, and group GM (n=15), where patients received mannitol 20%. Results Regarding demographic data, no statistically significant difference was observed between the two groups. There was a statistically significant decrease in mean arterial pressure in GH when compared with GM. There was a statistically significant increase in Na level in GH in comparison with GM. There was statistically significant decrease in K level in GH more than in GH. Regarding pH, there was no statistically significant between the two groups. Conclusion Intravenous infusion of HTS 3% is effective in decrease IOP in patients with glaucoma. It is considered a good alternative to mannitol for this purpose.
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