Abstract
A number of investigations were carried out previously on x-ray effects on the electrophysiological and mechanical properties of striated muscle. Only minor changes of membrane resting potential could be recorded during the first few hours following heavy x irradiation (80 to 250 kr) of frog-s santorius muscle. The membrane resting and action potentials were recorded with the intracellular microelectrode technique from papillary muscles of cats. An unfiltered x-ray source (50 kv, 25 ma) was used at dose rates of 20 and 25 kr/min at approximately 10 cm from the preparation for various exposures. The measurements were made at 5-min intervals for at least 1 hr before and after irradiation. The described radiation effects on heart muscle fibers resemble to some extent those obtained with 2.4dinitrophenol or iodoacetate after incubation of rat-s atrium in a solution of these substances. Woodbury reported similarities between the effects of x-rays and 2.4-dinitrophenol on striated muscle fibers. (B.O.G.)
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