Abstract
SummaryThe Vinca alkaloids, vinblastine, vincristine and vindesine, were examined for their effect on the basal cyclic AMP level and the hormonal response of mouse splenic lymphocytes. Both the β-adrenergic agonist, isoproterenol, and prostaglandin E1 were tested for their capacity to stimulate cyclic AMP synthesis in untreated, control splenocytes and splenocytes pretreated (30 min) with 10 [xM of the Vinca alkaloids. Vindesine was found to be the most potent of the three drugs in its capacity to increase the basal cellular cyclic AMP level and in enhancing the accumulation of cyclic AMP in response to either hormone. The effect of vindesine pretreat-ment on hormonal response was still observed and was even more pronounced than the other drugs 60 min after exposure to either hormone. Normally the cellular response to a hormone diminishes over this period of hormonal exposure, leading to a hormonally desensitized or refractory state.
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