Abstract
The ability of thiouracil to induce thyroid hypertrophy is believed to be mediated through a direct depression of thyroid hormone synthesis, thereby permitting increased thyrotrophic hormone production by the anterior pituitary and greater stimulation of the thyroid (MacKenzie and MacKenzie, 1943; Astwood et al., 1943). Underfeeding is believed to inhibit thyroid function through a direct depression of thyrotrophic hormone secretion by the anterior pituitary (Mulinos and Pomerantz, 1940, 1941; Stephens, 1940; and others). Thiouracil action therefore might be expected to be less effective in underfed than in normally-fed animals, since the initial thyroid and thyrotrophic hormone secretion rates wrould be lower than in normally-fed animals. In a previous report on the effects of starvation on thiouracil action in rats, Gomez Mont, Paschkis and Cantarow (1947) found that the hypertrophy and hyperplasia of the thyroids was less marked and developed later than in normally-fed controls.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
