Abstract
Background and aims. Remineralization of incipient caries is one of the goals in dental health care. The present study aimed at comparing the effects of casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP), Remin Pro®, and 5% sodium fluoride varnish on remineralization of enamel lesions.Materials and methods. In this in vitro study, 60 enamel samples were randomly allocated to six groups of 10. After four days of immersion in demineralizing solution, microhardness of all samples was measured. Afterward, groups 1-3 underwent one-time treatment with fluoride varnish, CPP-ACP, and Remin Pro®, respectively. Microhardness of groups 4-6 was measured not only after one-month treatment with the above-mentioned materials (for eight hours a day), but also after re-exposing to the demineralizing solution. The results were analyzed by one-way analysis of variance (ANOVA), repeated measures ANOVA, and Fisher’s least significant difference (LSD) test.Results. None of the regimens could increase microhardness in groups 1-3. However, one-month treatment regimens in groups 4-6 caused a significant increase in microhardness. The greatest microhardness was detected in the group treated with CPP-ACP (P = 0.001). In addition, although microhardness reduced following re-demineralization in all three groups, the mean reduction was minimum in the CPP-ACP-treated group (P < 0.001).Conclusion. While long-term repeated application of all compounds improved microhardness, the remineralization potential of CPP-ACP was significantly higher than that of Remin Pro® and sodium fluoride varnish.
Highlights
Dental caries prevention and arresting carious lesions are among the main objectives of dental health care
The present study aimed at comparing the effects of casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP), Remin Pro®, and 5% sodium fluoride varnish on remineralization of enamel lesions
One-way analysis of variance (ANOVA) results indicated the absence of significant differences in the mean baseline microhardness (P = 0.260), the mean microhardness after four days of demineralization (P = 0.330), and the mean microhardness after the first treatment (P = 0.120) between groups 1 to 3
Summary
Dental caries prevention and arresting carious lesions are among the main objectives of dental health care. Any disturbance in the balance of the oral cavity will destruct tooth structure.[1] At pH ≤ 5.5, the reaction between hydrogen ions, produced by bacterial metabolism, and the JODDD, Vol 9, No 4 Autumn 2015 phosphate group of enamel crystals leads to enamel dissolution/demineralization. This process can be reversed at normal pH and in presence of calcium and phosphorus ions. The present study aimed at comparing the effects of casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP), Remin Pro®, and 5% sodium fluoride varnish on remineralization of enamel lesions.
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