Abstract
Approximately 25.3 million adults suffer from chronic pain, often caused by chronic inflammatory conditions. We hypothesize that chronic inflammation negatively alters myofascial tissue structure and function. To better understand this process and test our hypothesis, we are developing a cell model to examine chronic inflammation in myofascial tissue. The goal of this investigation is to determine if chronic inflammation changes cell signaling of the myofascial tissue and lead to fibrosis. Human skeletal muscle (HSkM) cells and human fibroblasts make up the myofascial tissue. Therefore, we will first examine the relationship between the chronic inflammatory mediator, TNF‐alpha, and HSkM cell expression of TGF‐beta. We find that TNF‐alpha increases expression of TGF‐beta in HSkM cells changing the cell phenotype to a fibrotic state.
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