Abstract
Aim: Diabetes mellitus (DM) is a metabolic disease due to increased blood glucose, with multiple organ involvement. Although various oral drugs are used to treat DM, they do not prevent the development of DM related diseases such as cognitive disorder, neuropathy and vascular diseases. Thus novel strategies for the prevention and treatment of DM are urgently needed. This research aimed to reveal the effects of Thymus Vulgaris Lamiaceae (TVL) and Thymbra Spicata Lamiaceae (TSL) on the damaging effects of DM. Materials and Methods: Therefore, prepared TVL and TSL aqueous extracts were studied in the streptozocin induced experimental diabetic rat model. Blood glucose, body weight, and cognitive functions were examined. Morris water maze test was used to define the effect of TVL and TSL on DM related cognitive dysfunction. Results: Briefly, impaired blood glucose, and cognitive dysfunction of Diabetic rats were significantly improved by TVL in dose dependent manner (P
Highlights
Diabetes mellitus (DM) is the common metabolic disease referring to hyperglycemia due to the corruption of insulin secretion, insufficient insulin sensitivity, or both
Briefly, impaired blood glucose, and cognitive dysfunction of Diabetic rats were significantly improved by Thymus Vulgaris Lamiaceae (TVL) in dose dependent manner (P
Our findings strongly recommend the usage of TVL treatments for DM control by the DM patients
Summary
Diabetes mellitus (DM) is the common metabolic disease referring to hyperglycemia due to the corruption of insulin secretion, insufficient insulin sensitivity, or both. Type 1 DM (T1D) is an autoimmune disease characterized by the destruction of pancreatic ß-cells. Exposure of environmental harmful substances during neonatal period is accused of leading to initiation of immune process underlying the destruction of ßcells and the development of disorder [3]. Patients with Type 1 Diabetes (T1D) are presented with absolute insulin deficiency, and multiple types of insulin formulations have been developed for the treatment of T1D in the last three decades [4]. Type 2 Diabetes (T2D), non-insulin-dependent type of DM, is mainly an adult disease and associated with insulin resistance. The incidences of T2D rapidly increase due to the decrease in physical activity, sedentary lifestyle, and aging population
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