Abstract
PURPOSE: To determine whether interrupting prolonged sitting with three kinds of regular walking activity breaks has an immediate or delayed effect on postprandial triglyceride response. METHODS: In a randomized crossover trial, 16 inactive healthy adults (7 men, aged 21-30 years) completed four 26-h (from 8:00 AM on day 1 to 10:00 AM on day 2) laboratory conditions. Except for the 9-h intervention phase, the same procedure was used in the following four trials: (1) 9-h prolonged sitting (SIT); (2), (3), and (4) sitting with 3, 5, and 8 minutes of brisk walking (60% VO2max) every 35, 50, and 70 minutes, respectively (WALK3, WALK5, and WALK8). Postprandial serum triglyceride (TG) and nonesterified fatty acid (NEFA) were measured for 2-h dinner immediately on day 1 and for 2-h breakfast on day 2. Meals and meal times were standardized across the conditions for all the participants. RESULTS: Compared with SIT, only WALK8 significantly attenuated 2-h breakfast postprandial triglyceride total area under the curve (tAUC; SIT: median [Q1, Q2], 2.12 mmol·h·L−1 [1.46, 3.67] vs WALK8: 2.01 [1.25, 3.34], p = 0.041). The tAUC for 2-h dinner postprandial triglyceride and for both 2-h dinner and breakfast postprandial NEFA were not significantly changed in the three-activity break conditions. However, compared with SIT, the three-activity break conditions significantly increased the pre-dinner NEFA concentrations on day 1 (WALK3 52%, WALK5 36%, and WALK8 75%; all p < 0.05), but only WALK8 increased the fasting NEFA concentration on day 2 (25%; p < 0.05). No significant differences in all the above-mentioned indicators were found among the three-activity break conditions. CONCLUSIONS: The 8-min brief bouts every 70 min attenuated the postprandial triglyceride response measured about 24 h after, not immediately after, the intervention phase. Supported by the Shanghai Science and Technology Committee (No. 16080503300).
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