Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Abstract

Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans.
 Method: The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose. The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).
 Results: During the single dose, the HR was reduced at the end of the speech (86±2,0 to 74±3,0 bpm) the experimental group compared to the placebo group (p<0,05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1,0 (B), 111±1,0 (A), 121±2,0 (S1), 115±3 (S2), 104±2,0 (F) e Placebo: 121±3,0; 127±3,0; 130±3,0; 130±4,5; 117±3,0 (p<0,05).
 Conclusions: It is suggested that supplementation using Passiflora incarnata L. Capsules (500 mg) decreased cardiovascular signals both in single and in multiple doses, associated with the stress of public speaking.