Abstract
BackgroundThis study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, non-toxicity, and non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean women, with special emphasis on a development of natural substances with a high safety to relieve acne and minimize skin irritation.MethodsAfter a homogeneity test was conducted targeting 20 Korean women with acne skin, who have met the primary and the secondary clinical selection criteria, the subjects were divided into the treatment group with myrtle essential oil applied (the experimental group) and the no-treatment group with no myrtle essential oil applied (the control group) to use provided cosmetics every morning and evening for 6 weeks. To precisely check the effects of the myrtle substances, the provided cosmetics are made with only a difference in the presence or absence of added myrtle substances, leaving all other substances equal.ResultsThe acne grades significantly decreased in the experimental group with myrtle applied, with the pore index (outstanding pores, large pores, blackheads), the erythema index, the sebum index, and the desquamation index also decreased in the group. Lastly, the microorganism index decreased considerably in the experimental group, showing all evaluation indicators related to acne improved in the experimental group in a statistically significant manner. On the other hand, the acne grades a little decreased in the control group with no myrtle applied, but with no statistical significance, while the pore index (outstanding pores, large pores, blackheads), the erythema index, the sebum index, and the desquamation index rather increased to some extent. In addition, the microorganism index decreased in the control group, but with a smaller volume of changes than that in the experimental group.ConclusionThis study has clinically proved that myrtle essential oil has effects for convergence, reduction in erythema, removal of sebum and dead skin cells, and antibacterial activity on the facial skin of Korean women. Especially, this study confirmed that myrtle essential oil is a safe, skin-soothing substance effective for treating acne by showing the oil reduced the number of erythema.Trial registration-Name of the registry: Institutional Review Board of Korea Institute of Dermatological Sciences-Trial registration number 1-70005239-AB-N-01-2018-KIDS-AHA043-HR-01-Date of registration: March 2, 2018.
Highlights
This study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, nontoxicity, and non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean women, with special emphasis on a development of natural substances with a high safety to relieve acne and minimize skin irritation
Therapies are being presented for acne using glycyrrhizic acid, ginnarin, astemisic acid, berberine, hesperidin, etc., which are obtained from natural materials (Momin et al 2010; Del Rosso et al 2016; Boni and Nehrhoff 2003)
Homogeneity test Acne grades of subjects In terms of the acne grades, the experimental group consisted of five persons with grade 1 (50%), three persons with grade 2 (30%), one person with grade 3 (10%), and one person with grade 4 (10%)
Summary
This study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, nontoxicity, and non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean women, with special emphasis on a development of natural substances with a high safety to relieve acne and minimize skin irritation. Treatment substances currently applied to acne show rapid effects, but still many issues are being reported, including erythema, occurrence of resistant strains due to antibiotics, teratogenicity, pruritus, pyrosis, and hormonal side effects (Khunger et al 2008) To settle those issues, therapies are being presented for acne using glycyrrhizic acid, ginnarin, astemisic acid, berberine, hesperidin, etc., which are obtained from natural materials (Momin et al 2010; Del Rosso et al 2016; Boni and Nehrhoff 2003). Myrtle essential oil comprises 35.9% of myrtenyl acetate, an ester substance; 29.89% of 1,8-cineole, an oxide substance; and 8.18% of α-pinene and 7.58% of limonene, which are mono terpene substances (Battaglia 1997) These ester, oxide, and mono terpene-based substances present effects for convergence, soothing, prevention of germs, and reduction of dead skin cells (Ghasemi et al 2011; Battaglia 1997). This study aims to examine the impacts of myrtle essential oil on Koreans’ acne skin and to reveal its possibility to be used for cosmetics for acne skin with a high safety, which minimizes irritation to the skin without causing allergic reactions
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