Abstract

BackgroundLethal dose 50% is a classical index of toxicity that usually employs small rodents as experimental animals. Therefore, scarce data are available on the effects of venom on invertebrates, particularly the impact of wasp venom on its own species.FindingsIn the present study, the lethality of Vespa crabro venom on its own species was studied. Lethal dose 50% values of crude venom on workers of hornet Vespa crabro were estimated to be 4.0 mg/kg of body weight.ConclusionsWasps can use their venom apparatus effectively when attacking foreign workers that appear in the immediate vicinity of their nest. The toxins released during stinging are potent enough to kill. The result of this study eliminates the popular myth that venomous animals can be resistant to their own venom.

Highlights

  • Lethal dose 50% is a classical index of toxicity that usually employs small rodents as experimental animals

  • The classical method of determining the toxicity of a substance is the lethal dose 50% (LD50), which is often used in analysis of different animal toxins [1,2,3,4,5,6]

  • Almost all studies about venom activity are based on the lethality of small rodents including mice and rats

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Summary

Introduction

Lethal dose 50% is a classical index of toxicity that usually employs small rodents as experimental animals. Findings The classical method of determining the toxicity of a substance is the lethal dose 50% (LD50), which is often used in analysis of different animal toxins [1,2,3,4,5,6]. A few studies on the lethal activity of a venom on its own species demonstrated significant results [8].

Results
Conclusion
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