Abstract
Cyclin D1 (CCND1) is critical in the transition of the cell cycle from G1 to S phases and unbalanced cell cycle regulation is a hallmark of carcinogenesis. A number of studies conducted to assess the association between CCND1 G870A polymorphism and susceptibility to lung cancer have yielded inconsistent and inconclusive results. In the present study, the possible association above was assessed by a meta-analysis. Eligible articles were identified for the period up to November 2011. Pooled odds ratios (OR) with 95% confidence intervals (95%CI) were appropriately derived from fixed effects or random-effects models. Sensitivity analysis excluding studies whose genotype frequencies in controls significantly deviated from the Hardy-Weinberg equilibrium (HWE) was performed. Ten case-control studies with a total of 10,548 subjects were eligible. At the overall analysis the CCND1 870A allele appeared to be associated with elevated lung cancer risk (for allele model, pooled OR=1.24, 95% CI: 1.08-1.44, P=0.004; for homozygous model, pooled OR=1.45, 95% CI: 1.14-1.84, P=0.003; for recessive model, pooled OR=1.29, 95% CI: 1.06-1.58, P=0.013; for dominant model, pooled OR=1.33, 95% CI: 1.08-1.65, P=0.009). Subgroup analyses by ethnicity and sensitivity analysis further pointed to associations, particularly in Asians. This meta-analysis suggests that the A allele of CCND1 G870A polymorphism confers additional lung cancer risk.
Highlights
Lung cancer is one of the leading causes of cancer deaths in the world (Herbstet al., 2008)
Eligible studies A total of 10 case-control studies with a total of 10, 548 subjects on the association between cyclin D1 (CCND1) G870A polymorphism and lung cancer risk were included for this meta-analysis (Qiuling et al, 2003; Wang et al, 2003; Buch et al, 2005; Gautschi et al, 2006; Hung et al, 2006; Sobti et al, 2006; Wang et al, 2007; Wang et al, 2008; Li et al, 2009; Hsia et al, 2011)
Meta-analysis Table 1 listed the results of the association between the CCND1 G870A polymorphism and lung cancer, and
Summary
Lung cancer is one of the leading causes of cancer deaths in the world (Herbstet al., 2008). Considering the important role in the transition from G1 to S phase o the cell cycle, cyclin D1 (CCND1) is considered as an essential regulator for this process, whose deregulation has been implicated in pathogenesis of several types of cancers, including lung cancer (Knudsen et al, 2006; Musgrove et al, 2011). In order to reduce the probability of false-negative results and derive a more precise estimation of the association of CCND1 G870A polymorphism with lung cancer risk, we performed a meta-analysis based on the data from all related published literature. A number of studies conducted to assess the association between CCND1 G870A polymorphism and susceptibility to lung cancer have yielded inconsistent and inconclusive results. Conclusion: This meta-analysis suggests that the A allele of CCND1 G870A polymorphism confers additional lung cancer risk
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