Abstract
In guinea-pig hippocampal slices, activity of CA1 and CA3 neurons (pyramidal layer) during temperature changes was extracellularly recorded. A sharp increase in the rate of spontaneous bursts of action potentials as well as in the number of spikes in a burst during low-amplitude warming in a functional temperature range (36–40°C) was found. Cessation of warming was followed by a recovery of these parameters to the initial values irrespective of the temperature (between 32 and 40°C) at which stabilization occurred. In a functional temperature range (36–40°C), continuous slow cooling inhibited neuronal bursting activity. It is suggested that temporal extension of neuronal bursting in response to continuous temperature rise may play a role in the generation of febrile of febrile seizures.
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