Abstract
Superoxide dismutase (SOD) injected into mice prior to lipopolysaccharide (endotoxin) challenge enhanced mouse survival. However, mice administered prophylactic SOD at levels sufficiently above or below the optimum concentration were not protected. The levels of glutathione peroxidase and catalase in extracts from lungs of mice challenged with endotoxin did not change appreciably. SOD enzyme specifc activity in lung extracts was reduced about 50% within 1 hr of endotoxin challenge. The reduction in lung superoxide dismutase specific activity increased with increasing endotoxin dose. Reduction of superoxide dismutase specific activity in mouse lung following endotoxin challenge may be necessitated by a requirement for an elevated O 2 − concentration. Superoxide anion is a required substrate for at least one endotoxininducible enzyme found in mouse lung.
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