Abstract
1. Cytochrome P-450-dependent activities were measured in the liver, duodenum and kidney of mallard ducks ( Anas platyrhynchos) after pretreatment with known inducers of these enzymes (phenobarbital, β-naphthoflavone, polychlorobiphenyls, and two imidazole fungicides, prochloraz and imazalil). 2. Liver enzymes were highly induced by phenobarbital, and to a lesser extent by β-naphthoflavone. Considerable differences were found between ducks and rodents in the nature of monooxygenase acivities expressed after pretreatment with these two compounds. PCBs and fungicides caused only minor modifications in cytochrome P-450 level and enzymatic activities. 3. Extrahepatic enzyme activities were induced by phenobarbital, and were modified only slightly by other compounds.
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