Abstract
Significant decreases in state 3 oxygen consumption, respiratory control index (RCI), ADP: O ratio and phosphorylation rate were observed in the presence of 0.1–1.0 mM quinidine; 0.5 mM or greater concentratiions elevated state 4 oxygen consumption. Lidocaine (1–2.5 mM) also depressed RCI and increased state 4 oxygen consumption but procaine amide (1–2.5 mM) was without effect. It is suggested that cardiodepressin by quinidine may be associated with its ability to impair mitochondrial metabolism.
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