Abstract
The intestinal epithelium of the gastrointestinal (GI) tract constantly renews itself to absorb nutrients and provide protection for the body from the outside world. Since the intestinal epithelium is constantly exposed to various chemicals and dietary components, it is critical to determine which constituents promote or inhibit intestinal epithelium health and growth rate. Intestinal organoids, three-dimensional miniature models of the intestines, represent an ex vivo tool to investigate intestinal physiology and growth patterns. In this study, we measured the growth rates of murine intestinal organoids exposed to various concentrations of different dietary constituents. Results indicate that caffeic acid inhibited organoid growth in a concentration-dependent manner, curcumin exhibited variable effectiveness, and vitamin C had no effect on organoid growth.
Highlights
IntroductionA major function of the intestines is to absorb nutrients, liquids, and other substances into the body [1]
A major function of the intestines is to absorb nutrients, liquids, and other substances into the body [1]. This process is made possible through the intestinal epithelium, which are a layer of specialized cells on the mucosa that act as a barrier to harmful substances
We investigated the use of a murine intestinal organoid system as a model to study how various dietary constituents affect the growth rates of a functional gut system
Summary
A major function of the intestines is to absorb nutrients, liquids, and other substances into the body [1] This process is made possible through the intestinal epithelium, which are a layer of specialized cells on the mucosa that act as a barrier to harmful substances. Intestinal crypts reside at the bottom of the villi and contain stem cells, which replicate to produce progenitor absorptive cells, which mature as they migrate towards the villus tip. This is the process of intestinal epithelial renewal.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
