Abstract
Abstract Spirally cut sections of horse carotid artery have been found suitable for the qualitative testing of vasoconstrictors and their antagonists. With this preparation reserpine and hydrallazine non-specifically antagonise the contractions induced by a number of stimulant drugs, including adrenaline, noradrenaline, histamine, 5-hydroxytryptamine, acetylcholine, barium chloride and potassium chloride. Measurements of “self protection” by means of Furchgott's method but using strips of horse carotid arteries have shown that hydrallazine may possess an affinity for adrenergic receptors.
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