Abstract
Reserpine has been shown to markedly reduce the grooming behaviour and body temperature of mice. These effects were accompanied by a profound reduction of the transmitter content of central and peripheral serotonergic and adrenergic neurons. Treatment of mice with 6-hydroxydopamine and p-chlorophenylalanine, which reduced the transmitter content to the same extent as treatment with reserpine, had no effect on the grooming behaviour or on the body temperature. It is tentatively suggested that the effect of reserpine on the grooming behaviour and body temperature has no relation to the reduction of the transmitter content of central and peripheral serotonergic and adrenergic neurons.
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